• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar

Reviews from Broadway and Beyond

  • Now Playing
  • Recently Opened
    • Broadway
    • Off-Broadway
    • Beyond
  • Critics’ Picks
  • Our Critics
    • About Us
    • Melissa Rose Bernardo
    • Michael Feingold
    • David Finkle
    • Will Friedwald
    • Elysa Gardner
    • Sandy MacDonald
    • Jesse Oxfeld
    • MICHAEL SOMMERS
    • Steven Suskin
    • Frank Scheck
    • Roma Torre
    • Bob Verini
  • Sign Up
  • Facebook
  • Twitter
  • Now Playing
  • Recently Opened
    • Broadway
    • Off-Broadway
    • Beyond
  • Critics’ Picks
  • Our Critics
    • About Us
    • Melissa Rose Bernardo
    • Michael Feingold
    • David Finkle
    • Will Friedwald
    • Elysa Gardner
    • Sandy MacDonald
    • Jesse Oxfeld
    • MICHAEL SOMMERS
    • Steven Suskin
    • Frank Scheck
    • Roma Torre
    • Bob Verini
  • Sign Up
  • Facebook
  • Twitter
September 4, 2024 8:01 pm

Lifeline: A Penicillin Tuner, Yes, Penicillin!

By David Finkle

★★☆☆☆ Nobel Prize penicillin developer Alexander Fleming, with contemporary lovers singing

Kirsty MacLaren, Matthew Malthouse in Lifeline. Photo: Andrew Patino

Full marks for honorable intentions speed to the creators of Lifeline, a visiting musical presently onstage at Signature Theatre. Bookwriter Becky Hope-Palmer, composer-lyricist Robin Hiley and co-creators Alex Howarth and Jess Conway have devised a musical about Alexander Fleming and the development of penicillin. Who would have considered the history of penicillin as a likely candidate for musical dressing-up?

There may be those who argue that some subjects are strictly unfit for musicalization. On first hearing, penicillin — and the complex history of antibiotics — would be a prime contender for keeping musical hands off. But no. Naysayers are just stodgy. It’s documented that if executed by the right talent, anything is game.

Nonetheless, the undertaking is problematic. The people at Scotland’s Charades Theatre Company describe themselves as “passionate about the power of theatre to deal with important social issues.” Though Lifeline arrives here after successful tours and as a two-time sell-out at the Edinburgh Fringe Festival, what is on offer is somewhat confused, even shoddy craftsmanship.

In two lengthy acts Lifeline intertwines two stories. The first is that of Fleming (Matthew Malthouse), who notices a green mold denaturing infections afflicting wounded soldiers during The Great War. (He recalls the discovery in the Nobel acceptance speech that opens the production.) As years pass, he also recognizes devastating alterations to penicillin and other antibiotics as bacterial resistance builds.

The second major Lifeline thread involves Jessica (Kirsty MacLaren), a junior doctor at the Edinburgh Infirmary Hospital. She’s also known as Jess, especially to her musician boyfriend Aaron (Scott McClure), who, following a minor procedure, increasingly fights a hospital-induced infection not improved by available antibiotics. As he worsens, Jess and he are visited by his hopeful mother, Layla (Mari McGinlay) and good friend and politician Julian (Robbie Scott).

The resulting drama leads to dialog like this: “We start Camille [another weakened antibiotics sufferer] off with a six-week course of flucloxacillin, the first line of defense, but she doesn’t improve. When we do a dangerous biopsy, it turns out her staphylococcus is resistant to flucloxacillin — MRSA” — MRSA the deadly hospital-incurred infection impeding recovery.

During the two acts, bookwriter Hope-Palmer goes at her two tales. She presents the Jess-Aaron complications chronologically, while Fleming’s episodes dodge back and forth in aggressive, eye-and-ear-challenging ping-pong fashion. Moreover, and for a reason not made clear, a good deal of the second act unfolds during World War I. To provide opportunities for rousing wartime numbers?

Which brings up the score, in which two obligatory(?) ballads are touchingly rendered, “Waltz With Me” and “Stay With Me.” Yet, a sizable part of the inclusions focus on molds, as in “The Man Behind the Mold” and “Tip the Odds in Our Favor,” boasting the gleeful line “They had purified your old mold.” Possibly given the issue at hand, those are to be expected. Perhaps the same for choruses repeating the cries “Sinusitis, Tonsillitis, Conjunctivitis, Cystitis.”

The appropriate judgment to pass on Lifeline — which also manages to slip in a brief climate-change shout-out — is that, despite substantial acting under Alex Howarth’s hand, the purveyors have their hearts in the right place but not the acumen to make good on the honorable impetus.

Lifeline opened September 4, 2024, at  the Signature Theatre and runs through September 28. Tickets and information: lifelinemusical.com 

About David Finkle

David Finkle is a freelance journalist specializing in the arts and politics. He has reviewed theater for several decades, for publications including The Village Voice and Theatermania.com, where for 12 years he was chief drama critic. He is also currently chief drama critic at The Clyde Fitch Report. For an archive of older reviews, go here. Email: david@nystagereview.com.

Primary Sidebar

Sexual Misconduct of the Middle Classes: Let’s Hear It From the Boy

By Melissa Rose Bernardo

★★★★☆ Hugh Jackman plays a professor entangled with a student in Hannah Moscovitch’s 90-minute drama

Sexual Misconduct of the Middle Classes: Star Power Up Close

By Frank Scheck

★★★★☆ Hugh Jackman and Ella Beatty co-star in this intimate drama about a university professor who has an affair with one of his students.

The Black Wolfe Tone: Kwaku Fortune’s Forceful Semi-Autographical Solo Click

By David Finkle

★★★★☆ The actor, new to the Manhattan Stage, makes himself known, as does director Nicola Murphy Dubey

Five Models in Ruins, 1981: Dressed for Excess

By Michael Sommers

★★☆☆☆ Elizabeth Marvel shoots a gallery of swans in lovely circumstances

CRITICS' PICKS

Dead Outlaw: Rip-Roarin’ Musical Hits the Bull’s-Eye

★★★★★ David Yazbek’s brashly macabre tuner features Andrew Durand as a real-life desperado, wanted dead and alive

Just in Time Christine Jonathan Julia

Just in Time: Hello, Bobby! Darin Gets a Splashy Broadway Tribute

★★★★☆ Jonathan Groff gives a once-in-a-lifetime performance as the Grammy-winning “Beyond the Sea” singer

John Proctor Is the Villain cast

John Proctor Is the Villain: A Fearless Gen Z Look at ‘The Crucible’

★★★★★ Director Danya Taymor and a dynamite cast bring Kimberly Belflower’s marvelous new play to Broadway

Good Night, and Good Luck: George Clooney Makes Startling Broadway Bow

★★★★★ Clooney and Grant Heslov adapt their 2005 film to reflect not only the Joe McCarthy era but today

The Picture of Dorian Gray: A Masterpiece from Page to Stage

★★★★★ Succession’s Sarah Snook is brilliant as everyone in a wild adaptation of Oscar Wilde’s prophetic novel

Operation Mincemeat: A Comical Slice of World War II Lore

★★★★☆ A screwball musical from London rolls onto Broadway

Sign up for new reviews

Copyright © 2025 • New York Stage Review • All Rights Reserved.

Website Built by Digital Culture NYC.